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The review also confirmed GLP-1s cardioprotective and neuroprotective effects, its ability to decrease inflammation and apoptosis, and its roles in learning and memory, reward behaviour, and food palatability via central GLP-1R-expressing circuits
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In a meta-analysis of 60 studies involving 60,077 T2D patients, GLP-1RAs marginally reduced the UACR in comparison to placebo and other antidiabetic agents, but resulted in no clinically relevant changes in eGFR (Kristensen et al., 2019)
But for patients dealing with complex interactions between metabolic and mental health, this comprehensive approach with lower-dose medications as one component works really well
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