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When plotted, the 4 mg starting dose produces noticeably higher initial concentrations than starting at 2 mg, which is why the trial data showed more early gastrointestinal effects in the higher starting dose group
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10 In humans, oral doses of GSH 15 mg/kg increased plasma GSH 1.5- to 10-fold over the basal concentration in 4 of 5 volunteers tested
Int J Cardiol 357:123127 Holman RR, Bethel MA, Mentz RJ, Thompson VP, Lokhnygina Y, Buse JB, Chan JC, Choi J, Gustavson SM, Iqbal N et al (2017) Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes
Endocrinology (2013) 154:407888
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