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Its discovery traces back over 150 years to research on glucosuria ( By blocking sodium-glucose cotransporter 2 in the S1 and S2 segments of the proximal tubule, SGLT2i significantly reduce glucose reabsorption, promoting urinary glucose excretion

Because the elimination half-life is approximately one week and steady-state exposure builds over 4 to 5 weeks of once-weekly administration, exposure declines slowly, which is why the labels specifically contemplate a prolonged period of observation and treatment rather than a short one

It also prevents any new fat cells from forming

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3) and Eggers test ( P 2, suggesting a large effect size