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The genomic loci of rv1127c is adjacent to genes that encode essential enzymes of the methylcitrate cycle (MCC) (methylcitrate synthase (MCS and Rv1131c) and methylcitrate dehydratase (MCD and Rv1130c) and their transcriptional regulator (PrpR and Rv1129c) (Fig

Over 12 weekly doses, that is roughly 0.4mg of lost peptide

Elimination occurs primarily through renal clearance, with a plasma half-life of approximately 2-4 hours in rodent models

Bodanszky, M

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