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When tested as a once-daily injection in single and multiple doses varying up to 0.18 mg in healthy normal to overweight volunteers, gastrointestinal adverse events (nausea, diarrhoea, constipation, vomiting) were encountered, but the drug was described as well tolerated
Risks of any fracture and of forearm fracture were similar between the groups
10.1096/fj.09-149997 58 LimongiD.BaldelliS.ChecconiP.MarcocciM
While useful and still heavily relied upon, these traditional batch synthesis approaches can suffer from significant issues including complex impurity profiles due to incomplete reactions or double-addition, and significant challenges accessing difficult sequences [7], such as highly hydrophobic peptides that are prone to aggregation
Plos ONE 7 , e52570 (2012)
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