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Allergic Reactions Though rare, some people may have an allergic reaction to the components in the B12 injection
Proceedings of the National Academy of Sciences of the United States of America
Navigating the B12 road: assimilation, delivery, and disorders of cobalamin
Nausea: Mild gastrointestinal upset, linked to AMPK activation
Injectable routes carry a particular concern for immunogenicity from peptide aggregation and impurities, and FDA noted the available certificates of analysis for AOD-9604 bulk drug substances did not consistently control for impurities, aggregates, or microbial limits
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