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Journal of Biological Chemistry 285 , 3315433164, doi: 10.1074/jbc.M110.143685 (2010)

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Alpha class of GSTs, which is expressed in most tissues, including brain 45 , is specific for its substrate promiscuity as a consequence of protein flexibility and dynamics in the enzymes active site 46

Injectable forms are often considered more effective for systemic targets (tendons, joints, muscles) because they bypass digestive breakdown and provide higher bioavailability

Some patients find relief by taking the injection at a different time of day or by ensuring the medication has reached room temperature before injection