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Warning signs that require immediate medical evaluation include persistent bloody or black stools, severe abdominal pain, vomiting blood, signs of anemia (extreme fatigue, shortness of breath), or unexplained weight loss beyond expected results

52 Contraindications GLP-1RAs are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or in patients with multiple endocrine neoplasia syndrome type 2

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The same biological pathways remain active