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In sleep research models, DSIP administration has been associated with changes in delta wave (slow-wave sleep) architecture and sleep-wake cycle regulation

Serum BDNF levels are consistently lower in patients with major depressive disorder compared to healthy controls, and successful antidepressant treatment normalizes these levels

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Using the available research as a reference, the recommended starting dose of semaglutide is 0.25mg/weekly, and it should be increased every four weeks up to a maximum of 2.4mg/weekly [25, 26]