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Methods This meta-analysis adhered to a pre-registered protocol (PROSPERO ID: CRD42024538847)

Inflammation and oxidative stress associated with liver disease further accelerate glutathione depletion as it is consumed to protect liver cells from injury

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Pathogenic variants in the SCNN1B and SCNN1G genes are the causes of Liddle syndrome with pathogenic variants in the SCNN1B gene being identified in the individuals in the original pedigree of Liddle syndrome

Other research has focused on genetic and biochemical factors