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An analysis of data recorded between 2011 and 2023 from the TriNetX database, results indicate more than 800,000 patients became new users of GLP-1 receptor agonists during the period, with a marked increase in use beginning in 2020 as weight loss benefits began to emerge

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These data are consistent with the T allele decreasing risk for T2D, as well as decreasing glucose and HbA1c levels, but slightly increasing the risk of smoking initiation (Supplementary Table 16)