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For example, resolvin D1 has been shown to decrease the ratio of proinflammatory leukotriene B 4 to proresolving lipoxin A 4 via a kinase signalling pathway by means of which the nuclear:cytoplasmic ratio of 5lipoxygenase, the common enzyme in the biosynthesis of these two eicosanoids, is lowered

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however, this bleed surprisingly spontaneously resolved within 48 h with no clinical effect, which is very atypical for the natural history of this devastating disease where recurrent bleeds tend to become more severe

In a 2018 comprehensive review, Sikiric et al