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Disease-associated mutants, in general, can produce hydrophobic patches in the protein due to local misfolding, which will result in aggregation 46,47,48
2004;117(5):625-635.[DOI] 46
Besides, APX transcripts mainly consisted of 812 exons, supporting the relatively less conserved structure of APXs compared to GPXs
The process is facilitated by inhibition of cystine uptake by System Xc-, which reduces cellular GSH levels
Due to its presumed expense, however, some patients are hesitant to try them
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