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GIP receptor activation in adipose tissue appears to improve fat storage away from ectopic depots like the liver and muscle, which improves insulin sensitivity at those sites

Overall, tirzepatide reduced the AHI, body weight, hypoxic burden, high-sensitivity C-reactive protein concentration, and systolic blood pressure, and it improved sleep-related patient-reported outcomes

MAFA controls genes implicated in insulin biosynthesis and secretion

Last Updated July 2026 Author: Allison Jones, F-NP Medically reviewed by Dr

Furthermore, a 2018 study using NHANES data modeled the impact of obesity on mortality improvement between 1988 and 2011 and found that rising BMI levels reduced mortality improvement in the US by more than 0.5% per annum