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Consistent with other GLP-1 agonists, orforglipron labeling is expected to include the standard boxed warning about thyroid C-cell tumors and a contraindication in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Selective study citation Marketing highlights research showing that specific compounds can increase GLP-1 secretion, while omitting context about magnitude, duration, or clinical significance

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Without attention to fiber, hydration, and meal structure, constipation can persist throughout GLP-1 therapy