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Furthermore, in the absence of Cu 2+ , the apoenzyme component of the active enzyme becomes non-functional, halting the synthesis of Cu-SOD
X.CarvalhoC.CardosoS.CandeiasE.SantosM
Given the significant roles of NADPH in numerous pathways of reductive biosynthesis and in the maintenance of cellular redox status, in both the cytosol and the mitochondria, it is not surprising that there are multiple cytoplasmic and mitochondrial enzymes that have, as a product of their reactions, the reduced electron carrier, NADPH
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