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PMC 11059979

This approach is best exemplified by targeting two or three class B1 G protein-coupled receptors, namely, glucagon-like peptide-1 receptor (GLP-1R), glucagon receptor (GCGR) and glucose-dependent insulinotropic polypeptide receptor for treatment of type 2 diabetes and obesity

Tirzepatide, however, activates both the GLP-1 receptor and a second hormone pathway called glucose-dependent insulinotropic polypeptide (GIP), producing greater improvements in insulin sensitivity, weight loss and metabolic inflammation

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