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Altered bacterial secretome impact cytokine response of human cells

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Since PD patients are frequently on multiple therapies, it will be important for future studies to determine the independent effect of these therapies on the gut microbiome and their potential roles in the progression and management of the disease

In male reproductive pathology, ROS generated by mitochondria in asthenozoospermic sperm cause nuclear DNA strand breaks [358] and compromise chromatin condensation integrity through aberrant histone methylation patterns, which directly correlates with diminished sperm quality [351]