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and abroad Over the past three decades, the share of Americans categorized as obese (based on body mass index, or BMI, data from the CDC) has risen considerably

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doi: 10.1038/s41394-022-00525-7 236 RathnayakeLBaminiwattaAChandradasaMFernandoL

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When to contact your GP: Persistent or severe nausea/vomiting preventing adequate fluid intake Severe, persistent abdominal pain which could indicate pancreatitis New or worsening depression, anxiety, or suicidal thoughts Severe headaches or visual disturbances Unexplained cognitive changes or confusion Signs of hypoglycaemia (if taking alongside insulin or sulfonylureas) NICE guidance recommends regular monitoring during GLP-1 receptor agonist therapy

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