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This reduces fine lines and wrinkles, particularly in areas like the forehead, between the eyebrows (frown lines), and around the eyes (crows feet)

Edema usually subside

GLP-1 is a hormone produced by the small intestine with multiple roles, including triggering insulin release from the pancreas to reduce blood sugar, blocking glucagon secretion, slowing stomach emptying, and boosting satiety

Abbreviations DM: Diabetes Mellitus CD: Cognitive Dysfunction TNF-: Tumor Necrosis Factor- NDDG: The National Diabetes Data Group T1D: Type 1 Diabetes T2D: Type 2 Diabetes GD: Gestational Diabetes HIV: Human Immunodeficiency Virus BBB: BloodBrain Barrier GABA-A: -aminobutyric acid-A IR: Insulin Receptor PGC-1: Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1 SIRT1: Sirtuin 1 NF-KB: Nuclear Factor Kappa-Light-Chain-Enhancer of Activated cells FOXO: Forkhead box O IL-6: Interleukin 6 AGE: Advanced Glycation End Products A: Amyloid Beta PINK1: PTEN-induced putative kinase 1 TNF: Tumor necrosis factor PKC: Protein Kinase C AChE: Acetylcholinesterase CAT: Catalase LDL-C: Low-Density Lipoproteins-Cholesterol HbAlc: Hemoglobin A1c GSK3B: Glycogen Synthase Kinase-3 Beta ApoE-4: Apolipoprotein E-4 Allele Expression STZ: Streptozotocin BW: Body Weight STZ-NA: Streptozotocin-Nicotinamide p.o.: Per Oral BDNF: Brain-Derived Neurotrophic Factor AD: Alzheimer's Disease ERK: Extracellular Signal-Regulated Kinase PPAR-: Peroxisome Proliferator-Activated Receptor-Gamma PPAR-: Peroxisome Proliferator-Activated Receptor-Alpha PPAR: Peroxisome proliferator-activated receptor IRS: Insulin receptor MAPK: Mitogen-activated protein kinase FA: Fatty acids ROS: Reactive Oxygen Species RNS: Reactive Nitrogen Species LPO: Lipid peroxidation HO-1: Heme Oxygenase 1 GLUT4: Glucose transporter type 4 Bcl-2: B-cell lymphoma 2 Nrf2: Nuclear Factor Erythroid 2Related Factor 2 Glucose-6-P: Glucose 6-phosphatase mRNA: Messenger RNA A: Amyloid beta IFN-: Interferon-Gamma TGF-: Transforming Beta Growth Factor HFD: High-Fat-Diet PI3K: Phosphoinositide 3-kinase AKT: Protein kinase B GS: Glycogen synthase IL-1: Interleukin-1 GSK3: Glycogen synthase kinase-3 beta DPP4: Dipeptidyl peptidase-4 inhibitor MDA: Malondialdehide NMDA: N-methyl-D-aspartate GSH: Glutathione Peroxidase SOD: Superoxide dismutase CREB: Cyclic-AMP response element binding pGSK3: Phosphorylated Glycogen Synthase Kinase 3 References Abbas1, M

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