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Retinol and its derivatives work by accelerating cell turnover through vitamin A signaling pathways and often cause irritation, especially during initial use
doi: 10.1038/s41392-021-00507-5 160 EliasEELyonsBMuruveDA
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By strengthening jawbone, calcium helps protect the teeth from attacks brought on by bacteria, and lowers the chances of fractures in older individuals
In particular, for the parallel design studies (treated versus untreated patients or different treatments), the small sample sizes could have led to ineffective randomization and potential confounding, while in longitudinal (non controlled) trials it is difficult to draw any firm conclusion
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