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13 Another hallmark of post-traumatic DD is the over-expression of matrix-catabolic enzymes of the matrix metalloproteinases family (MMPs), especially of MMP1, -3, -13, which are all collagenases
Two strategies that accomplish this are replacement of GLP-1, glucagon-like peptide-1, with long-acting analogs or inhibition of DPP-4, the enzyme responsible for GLP-1 degradation
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