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PMID: 35658024 Jastreboff AM, et al
Oral GLP-1 weight loss medication Orfoglipron (Eli Lilly) is nearing an FDA decision with available expect mid-2026 Clinical trials show meaningful results: 12-16% 1,2 average weight loss, which is slightly less than injectables Side effects are similar: mostly gastrointestinal, such as nausea or diarrhea, typically improving over 23 months
Finally, descriptive statistics were used to analyze safety endpoints of the randomized treatments in all participants that were exposed to at least one dose [1]
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