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Nature 487 , 114118 (2012)

The reasoning is straightforward: when two thiols come together to form a disulphide, they lose hydrogens a process the chemistry of the cell recognises as oxidation

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Peptide 20 was developed through a series of optimizing processes based on GCGR agonism in diet-induced obese mice, concluding that the ideal metabolic benefits of triagonism predominantly depend on fine-tuning the GCG component 22