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Aggregation occurs when peptide chains misfold and clump, rendering them biologically inactive and potentially immunogenic if used in vivo models
Due to the expression of DPP4 by, and presentation in the plasma membrane of activated T-cells, endothelial cells, epithelial cells, and fibroblasts, chemokines have a high probability of interacting with the membrane-bound extracellular DDP4
The approval was expanded in October 2025 to include cardiovascular risk reduction in people with Type 2 diabetes
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