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Mitochondrial ROS can further support ICD by activating the RIP1-RIP3 necrosome pathway [148, 149] and generating oxidized mitochondrial DNA that triggers the STING-TBK1-IRF3-IFN- axis in dendritic cells, thereby enhancing CD8 T-cell priming [150]
Action Mechanism: The Accelerator Pedal Imagine that your pituitary gland is a coach
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