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They don't directly target the brain-gut axis the way some IBS-specific medications do, but they support the underlying gut tissue and immune signaling

The Danish drugmaker said Monday that Wegovy will no longer be available on Hims & Hers and that it is ending the collaboration because the San Francisco-based online health company sold "illegitimate, knockoff versions of Wegovy that put patient safety at risk." Novo Nordisk's move to dissolve the partnership came less than two months after the companies said they were entering a "long-term collaboration" to make obesity treatment more accessible

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In the clinical trials of retatrutide, dose escalation was paused or reduced when participants experienced intolerable side effects, most commonly gastrointestinal symptoms such as nausea, vomiting, or diarrhoea