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Also, it was added to topical N-acetyl glucosamine and ellagic acid in treatment of melasma Bissett and colleagues, Junyaprasert and colleagues
Since there was no significant difference of the mRNA level of GCS-HS and GS between control and proline group at any time points, it can be assumed that the activity of GCS in proline group might be upregulated by the upregulation of regulatory subunit of GCS, leading to the significant upregluation of total GSH from 6 h to 12 h
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