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Further, one chaperone upregulated during the UPR is Protein Disulfide Isomerase (PDI), which is an essential redox-sensitive activator of PERK (Kranz et al., 2017)

Glucagon also has a glucose-raising tendency on its own, which the two incretin arms counterbalance

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Physical therapy integration Synergistic benefits: Physical therapy provides mechanical stress stimulating tissue remodeling (Wolff's Law for bone, mechanical loading for tendon/ligament)

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