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Synthetic analogs mimic its active sequence by adding modifications that resist this enzymatic degradation

It is accompanied by cardiovascular benefits, including significant blood pressure reduction, lipid improvements, and dramatic weight loss, that almost certainly produce a net positive cardiovascular effect

10.1056/NEJM199012133232404 141 WuA

This creates a legal pathway for access, though it places responsibility on individuals to understand they are working with compounds not approved for human therapeutic use in Canada