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DPP-4 degrades GLP-1 (7-36) into the non insulinotropic GLP-1 (9-36) (some studies suggest it may have weak insulinotropic activity)
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Careful monitoring is recommended for patients with a history of pancreatitis, severe gastrointestinal disease, or diabetic retinopathy
In this study, performed in non-diabetic volunteers during an intravenous glucose load, GLP-1 greatly enhanced insulin release, reduced glucagon concentrations and significantly reduced peak plasma glucose concentrations, compared with a control saline infusion
Readers comparing WellMedr to other GLP-1 telehealth programs should focus on five questions: whether the medication is compounded or FDA-approved, who makes the prescribing decision, which pharmacy dispenses the medication, what the refund policy actually allows, and what safety disclosures are provided before payment
