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2007: A small, multicenter clinical study among 56 people with neuropathy associated with antiretroviral drug therapy showed that receiving 500 mg of acetyl-L-carnitine twice daily intramuscularly for two weeks, followed by 1,000 mg twice daily orally for 6 weeks, reduced pain by 0.89 points (on a 010 scale) compared to placebo

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7 A meta-analysis also identified a trend toward testosterone reduction, alongside increased sex hormone-binding globulin (SHBG), which further reduces the amount of biologically active testosterone

Low glutathione also increases the risk of developing hemolytic anemia (in which red blood cells are destroyed faster than they can be replaced), metabolic acidosis (an electrolyte disorder) and CNS dysfunction

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