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It has been shown that GLP-1RA semaglutide can improve working and spatial memory in transgenic AD modelling APP/PS1/tau (3xTg) mice, promote the release of anti-inflammatory factors and inhibit the production of pro-inflammatory factors in the cerebral cortex and hippocampus, as well as reduce the deposition of -amyloid in the CA1 subfield of the hippocampus

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While its successor semaglutide offers greater weight loss efficacy and the convenience of weekly dosing, liraglutide remains a clinically validated option backed by extensive trial data and the longest real-world safety record in its class

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25 , e12730 (2020)