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use within 24 weeks and avoid freezethaw [7]
It has also been shown that hypoxia stimulates PI3K/Akt/mTOR pathway to increase VEGF-A production and promote vascular invasion in the growth plate (22,23), likely in coordination with IGF-I
Most studies were of the case control design, however, additionally there were two double blinded [64, 65] and one open labelled randomised controlled trial [49], a case series [66] and a case report [54]
Dong L, Yang F, Li J et al (2022) Effect of oral alpha-lipoic acid (ALA) on sperm parameters: a systematic review and meta-analysis
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