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A study indicates that 6% to 15% of opioid-nave post-op patients became chronic opioid users after major or minor surgery, including 4% of those who underwent total hip arthroplasty and 8% of total knee arthroplasty

2003, 41: S116-122

There remains an unmet need for weight-management medications that can facilitate nonsurgical, sustained weight reduction and reduce pain in persons with obesity-related knee osteoarthritis, they added