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The SURPASS program established efficacy in type 2 diabetes across multiple comparators, including head-to-head superiority versus semaglutide on HbA1c reduction in SURPASS-2 (Fras et al., NEJM, 2021)
Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy
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The placement of waters was confined to AMY 1 R:Cagri and CTR:Cagri ( N = 1) within the deep binding pocket in order to avoid over interpretation of the cryo-EM maps
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