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Most people on either medication experience side effects that improve significantly after initial adjustment periods

A maintenance program is recommended, and is safe for ongoing use and benefits, much like taking a potent dose of vitamins every 2-3 weeks but through an IV

But it is simpler than most people expect

Esomeprazole and aspirin in Barretts oesophagus (AspECT): a randomised factorial trial

Simple timing framework Baseline Discuss baseline labs before starting or changing dose, especially with diabetes, kidney disease, pancreatitis history, gallbladder history, thyroid cancer history, or major calorie restriction