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For example, exposure of myometrial strips, removed at the time of cesarean section, to CRH enhances the inotropic action of oxytocin.211 Finally, CRH appears to upregulate the activities of mediators such as matrix metalloproteinase-1 and -3 and IL-8, which promote cervical ripening preceding labor.212 Thus, CRH may have direct and indirect effects that promote parturition

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This is especially true for collagen and antioxidants

This indicates that while TLR4 activation does play a role in MUN placental pathology, including its potential to increase inflammation in the placental environment and augment oxidative stress, it is instead specifically the resulting oxidative stress (particularly mROS) that plays a prominent role in the insufficiencies of the MUN placenta

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