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But for those with targeted needs, absorption may be limited
Across the controlled trials Volek's recovery work (PMID 11788381), the 2021 recovery trial (PMID 34684429), the centenarian fatigue trial (PMID 18065594), and the trials pooled in the 2016 weight meta-analysis (PMID 27335245) L-carnitine was generally well tolerated, with adverse events that were mild and did not drive meaningful discontinuation
Notably, 70% of plasma homocysteine is eliminated by the kidney
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All of those require a known target
Interestingly enough, oxidative stress did not affect the severity of depression
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