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Medications such as opioids, ones affecting gastrointestinal motility, or anticholinergic agents will not particularly benefit from combining semaglutide with their current administration without prior advice from their healthcare providers 9 Potential non-responders : There might be certain individuals who might be afflicted with other underlying diseases, who might not respond accurately to semaglutide therapy
Overall, the trials found that a lower starting dose (2 mg) during the dose increasing phase could help reduce the frequency and severity of GI side effects, compared to a higher initial dose (4 mg)
10.3390/jof4020060 J
Regular follow-up appointments should include heart rate and blood pressure measurements, particularly during dose escalation and the initial months of therapy
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