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It also explains why the final FDA response matters: the committee did not reach anything close to consensus, and FDAs own scientific review remained negative

With the rise in peptide popularity in recent years, many companies have created peptides that undergo little to no testing, quality standards, or regulations

Reference: Japjec M, Horvat Pavlov K, Petrovic A, et al

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However, some patients receiving high-dose B12 supplementation or injections may experience adverse reactions, though these relate to the treatment rather than the elevated levels: Possible reactions to B12 supplementation (particularly injections): Skin reactions, including acneiform eruptions or rashes Pruritus (itching) Injection site reactions (with parenteral administration) Rare hypersensitivity reactions Non-specific symptoms such as headaches, dizziness, or gastrointestinal disturbances have been reported by some patients taking B12 supplements, but causality is not well established in clinical evidence