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Pericyte response to ischemic stroke precedes endothelial cell death and blood-brain barrier breakdown

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GPVI ligation leads to phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) on the FcR chain, activating Syk, PLC2, and downstream IP 3 -DAG signaling for Ca 2+ mobilization (Moroi et al., 2021)

Serious cardiac arrhythmias were not reported to be more common in tirzepatide-treated patients compared to placebo groups in completed trials, providing context about the cardiac safety profile of the medication when used as directed

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