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It has been suggested that the FDA-approved dose of 50 mg daily is not sufficient to stimulate human BAT due to low 3-adrenergic receptor expression in human supraclavicular BAT and the effect seen with high doses of mirabegron are instead due to 2-adrenergic receptor agonism [149]
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Endocrinology 162 , bqab079 (2021)
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The behavioral component matters too
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