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Amylin-induced central IL-6 production enhances ventromedial hypothalamic leptin signaling
As an antioxidant, it could potentially reduce the effectiveness of some chemotherapy drugs that rely on the generation of free radicals to kill cancer cells
Alsolaiman MM, Howard L
Therefore, IGF2R may act as a tumor suppressor by preventing IGF1R activation
Additionally, lipophagy, the degradation of lipid droplets, results in increased lipid release, leading to lipid peroxidation and ferroptosis [132]
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