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In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver
Acyl-GIP abolished the avoidance effect of PYY in control GIPR AP-GFP animals but not in GIPR AP-KO animals (Fig
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In particular, L-carnitine reduces the expression of glial fibrillary acidic protein, inducible nitric oxide synthase, ubiquitin and caspase 3 typical markers of cell stress
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