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Like natural IGF-1, IGF-1 LR3 binds to the IGF-1 receptor (IGF-1R) , a tyrosine kinase receptor located on the cell surface

& Sullivan, J.rW

Intriguingly, in the trx3 , trr2 , and prx1 strains we observed either no E GSH response ( prx1 ) or an E GSH response that was greatly decreased compared to wildtype cells ( trx3 , trr2 ), following the addition of exogenous H 2 O 2 at an initial concentration of 1 mM (Fig 3A)