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Concomitantly, the increased levels of insulin reduce the binding of liver sex hormone binding globulin SHBG to testosterone, leading to hyperandrogenism (153)

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adrenal medulla Muscarinic receptors mediate their responses by G-proteins(GPCRs) Nicotinic receptors mediate their responses by opening a cationic ion channel that is an intrinsic component of the nicotinic-receptor-channel complex (e.g