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In the 50s, when chemotherapy wasnt yet available, massive doses of B12 shots were given to children with a neuroblastoma tumor every two days, for 2-3 years with great success: NEUROBLASTOMA: AN EVALUATION OF ITS NATURAL HISTORY AND EFFECTS OF THERAPY, WITH PARTICULAR REFERENCE TO TREATMENT BY MASSIVE DOSES OF VITAMIN B12

A three-domain architecture with a serine protease-like triad at the active site

Triple action mechanism After being absorbed through the nasal mucosa, MT-2 peptide rapidly reaches the hypothalamus via the trigeminal-sympathetic nerve pathway, activates the melanocortin receptor system, and triggers the release of melanocyte-stimulating hormone from the pituitary gland, forming a "neuro-endocrine-skin" cascade reaction

Liver Physiol

Es fundamental comenzar con una dosis ms baja para evaluar la tolerancia y la eficacia