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GLP-1R Expression (Or Not) The first descriptions of GLP-1(7-36) amide binding to a putative receptor in the brain ( The B class of GPCRs is a relatively small group of receptors but, nevertheless, one that is important in metabolic diseases such as diabetes and obesity ( Without a complete and accurate overview of target expression at the cellular level, it is difficult to fully understand the often complex intracellular signaling and the resulting metabolic effects
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Additionally, erythrocytes can scavenge chemokines via Duffy antigen receptor for chemokines (DARC), leading to changes in their availability and consequent regulation of immune cell migration [57]
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