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They originate from the same pluripotent stem cells as well as the other cell lines of the intestinal epithelium
They are simply not there yet
Consistent weekly injection timing matters more for drugs with half-lives near the dosing interval
Thyroid evidence boundary Jastreboff 2023 ( NEJM , NCT04881760), Rosenstock 2023 ( Lancet , NCT04867785), Sanyal 2024 ( Nature Medicine , NCT04881760), and the posted TRIUMPH-1 and TRIUMPH-4 toplines did not publish targeted Free T3, Free T4, or TSH outcomes
But clinical trials enroll carefully selected patients
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